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Papers on Alzheimer’s slapped with expressions of concern – Retraction Watch

Papers on Alzheimer’s slapped with expressions of concern – Retraction Watch
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A Science journal issued expressions of concern for 2 papers on Alzheimer’s illness on considerations concerning the integrity of the information.

One includes a 2016 article by a star-studded group of neuroscientists on allegations of manipulated knowledge in one of many figures. That article, “Acquire-of-function mutations in protein kinase Cα (PKCα) might promote synaptic defects in Alzheimer’s illness,” appeared in Science Signaling and comes from a staff led by Rudolph Tanzi and Roberto Malinow, of Harvard and UC San Diego, respectively.

Right here is the discover for the newspaper, which was quoted 64 occasions, based on Clarivate’s Internet of Science:

Science Signaling publishes an editorial expressing concern concerning the analysis article, “Win-from-function mutations in protein kinase Cα (PKCα) might promote synaptic defects in Alzheimer’s illness,” by Stephanie Alfonso and colleagues. The editors of the journal had been made conscious of accusations of information manipulation with respect to Determine S1, which is being investigated. The journal publishes this Editorial Expression of Concern to make readers conscious of those allegations whereas we await the result of the investigation.

The second article, “The amyloid-β oligomer Aβ * 56 induces particular alterations in neuronal signaling that result in tau phosphorilation and aggregation,” was revealed in 2017. The group of authors differs from the 2016 work – besides for 2 co-authors, Mathew Sherman and Sylvain E. Lesné, each from the Division of Neuroscience on the College of Minnesota, Minneapolis.

The discover for that newspaper, which has been quoted 50 occasions, reads:

Science Signaling publishes an editorial expression of concern concerning the analysis article, “The amyloid-β-oligomer Aβ * 56 causes particular adjustments in neuronal sign resulting in tau phosphorylation and aggregation” by Fatou Amar and colleagues. The editors have been made conscious of allegations of information manipulation with respect to Figures 1A, 3A, 6G, S9D and S12A, that are being investigated. The journal publishes this Editorial Expression of Concern to make readers conscious of those allegations whereas we await the result of the investigation.

We emailed Sherman and Lesné for remark and obtained this assertion from the College of Minnesota:

We’re conscious that questions have arisen about sure photos utilized in peer-reviewed analysis publications written by College College Karen Ashe and Sylvain Lesné. The College will comply with its processes to overview the questions raised by any claims. Presently we’ve got no additional info to offer.

The 2 articles in Science Signaling are amongst 10 papers by Lesné relationship from 2003 marked on PubPeer for questions concerning the figures. Two of these papers – one within the Journal of Neuroscience and one in Mind – had been corrected. Of the ten papers, Ashe contains as co-author.

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