Pricey Dr. Roach: I’m involved that my 33-year-old daughter will develop breast most cancers. My household has no historical past of breast most cancers, however my husband’s grandmother, mom, and sister all had breast most cancers and had bilateral mastectomies.
Pricey Dr. Roach: I’m involved that my 33-year-old daughter will develop breast most cancers. My household has no historical past of breast most cancers, however my husband’s grandmother, mom, and sister all had breast most cancers and had bilateral mastectomies. I’ve heard that DNA follows the mom’s facet and never the daddy’s facet. Is that this true or an previous girl’s story? Ought to she have a BRCA take a look at?
Most breast most cancers instances are sporadic, that means there isn’t any notably identifiable household danger for breast most cancers. Nonetheless, there are established genetic dangers, notably together with BRCA1 and BRCA2 genetic variants, that warrant testing in some instances.
The rules for testing one’s BRCA1/2 are complicated, and I do not even have sufficient area to summarize them right here. Nonetheless, the household historical past you present might not be sufficient to advocate genetic testing (except there are different elements, equivalent to Ashkenazi Jewish background). The kind of breast most cancers (equivalent to “triple adverse” breast most cancers) and the age at which a member of the family is recognized are additionally vital.
The genes for BRCA1/2 are autosomal, not X-linked, which implies that it does not (very) matter if they arrive from the mom or the daddy. Refined variations as a result of epigenetic adjustments might imply that individuals who inherit BRCA2 from their fathers are usually youthful than those that inherit breast and ovarian cancers from their moms.
Ideally, individuals with most cancers (breast, ovarian, pancreatic and prostate cancers are all affected by the BRCA gene) needs to be examined not just for BRCA1/2, but additionally for different newly found genetic predisposition genes.
One of the best recommendation on whether or not testing is suitable on your daughter comes from a genetic counselor.
Pricey Dr. Roach: Are research suggesting that consuming plums each day can delay or stop osteoporosis in postmenopausal ladies efficient? thanks.
a number of sclerosis
A number of research counsel that consuming plums might profit bones. In some research, ladies who ate 4 ounces of plums a day (and a management group ate dried apples) had blood exams that confirmed decreased bone turnover. Bone density research have proven that girls who ate plums had some profit or a minimum of slowed the decline in comparison with a management group. The length of the research was measured in months—fairly quick, because it often takes two years to see advantages in bones, which change slowly.
The sort of analysis won’t ever be accepted for brand spanking new medicine to deal with osteoporosis, which require dramatic enhancements in bone power or, higher but, a diminished danger of fractures. Nonetheless, plums have few unintended effects and have been consumed for hundreds of years. Plums are recognized to be efficient in treating constipation (which is usually a drawback for individuals with free stools). Each women and men can develop osteoporosis, though solely ladies had been concerned within the plum analysis.
In comparison with at present out there therapies for osteoporosis, prunes are very secure, though much less prone to deal with critical issues. They could not stop an individual from needing further therapy, however they might be useful.
Dr. Roach regrets that he can not reply to particular person letters, however will attempt to mix them into columns each time potential. Readers can electronic mail inquiries to ToYourGoodHealth@med.cornell.edu